Endocrine Abstracts

Objective: The aim of this single centre prospective open trial was to evaluate the long-term efficacy of octreotide LAR in acromegaly patients and possibility of withdrawal of this therapy.Methods: In total 17 patients with acromegaly diagnosed at Endocrinology Clinic in Sarajevo, somatostatin sensitive (ten females and six males, age range 37–65 years, six patients with microadenoma and ten patients with macroadenoma) were treated with octreotide....

Introduction: Polycystic ovary syndrome (PCOS) affects 5-10% of reproductive aged women. PCOS also manifests a chronic pro-inflammatory state. Estradiol is known to modulate the actions of immune cells, and, therefore, the antiviral mechanisms of these cells could also be modified by this hormone stimulus. In the presence of vitamin D, the binding energy of the spike protein to ACE2 was increased and transferring Apo to Locked S conformer of spike trimer was facilitated. Toget...

Objective: The aim of this single centre prospective open trial was to evaluate the long-term efficacy of octreotide LAR in acromegaly patients.Methods: In total of 19 patients with acromegaly diagnosed at Endocrinology Department of Clinical Centre of University in Sarajevo, somatostatin sensitive (ten females and eight males, age range 40–68 years, six patients with microadenoma and 12 patients with macroadenoma) were treated with octreotide. Foll...

Introduction: The correlation of subclinical hypothyroidism (SH) and polycystic ovary syndrome (PCOS) is a still insufficiently explored entity. It is known that the patients with PCOS are at the greatest risk of infertility as well as cardiovascular morbidity and mortality. The aim of this study was to determine the existence of correlation between SH and PCOS. We also aimed to investigate the impact of SH on the metabolic and endocrine parameters in women with PCOS.<p cl...

Selenium (Se) is a micronutrient of vital importance to human health. It acts as an antioxidant, immunomodulator and also it is involved in the control of specific endocrine pathways. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. The literature suggests that selenium supplementation of patients with Hashimotos thyroiditis is associated with a reduction in antithyroperoxidase antibody levels. Selenium supplementation also in mild Gr...